PMO-150 Second harmonic generation microscopy of collagen and evaluation of liver fibrosis in chronic hepatitis C (CHC) infection: Abstract PMO-150 Figure 1
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چکیده
منابع مشابه
Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy
Liver fibrosis assessment by biopsy and conventional staining scores is based on histopathological criteria. Variations in sample preparation and the use of semi-quantitative histopathological methods commonly result in discrepancies between medical centers. Thus, minor changes in liver fibrosis might be overlooked in multi-center clinical trials, leading to statistically non-significant data. ...
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Chronic hepatitis C (CHC) is a major public health concern, with around 180 million individuals affected worldwide. Liver fibrosis and its end-point cirrhosis are the main causes of morbidity and mortality in patients with CHC. Liver biopsy (LB) has traditionally been considered the "gold standard" for pre-treatment evaluation of liver fibrossis in patients with CHC. However, LB is an invasive ...
متن کاملEx vivo imaging and quantification of liver fibrosis using second-harmonic generation microscopy.
Conventionally, liver fibrosis is diagnosed using histopathological techniques. The traditional method is time-consuming in that the specimen preparation procedure requires sample fixation, slicing, and labeling. Our goal is to apply multiphoton microscopy to efficiently image and quantitatively analyze liver fibrosis specimens bypassing steps required in histological preparation. In this work,...
متن کاملFibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy.
We develop a standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm. Liver fibrosis is associated with an abnormal increase in collagen as a result of chronic liver diseases. Histopathological scoring is the most commonly used method for liver fibrosis assessment, where a live...
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ژورنال
عنوان ژورنال: Gut
سال: 2012
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2012-302514b.150